Mn(II), Co(II) and Zn(II) complexes with heterocyclic substituted thiosemicarbazones: Synthesis, characterization, X-ray crystal structures and antitumor comparison

Transition metal complexes Mn(L-1)(2) (1), Mn(L-2)(2) (2), Co(L-3)(2)Cl 4H(2)O (3), Zn(L-3)(2) DMF (4), Co(HL4)(2)(ClO4)(2) 3H(2)O (5) and Zn(L-5)(2) DMF (6) where HL1 = 2-acetylpyridine thiosemicarbazone, HL2 = 2-acetylpyridine N (4)-methylthiosemicarbazone, HL3 = 2-benzoylpyricline thiosemicarbazone, HL4 = 2-benzoylpyridine N (4)-methylthiosemicarbazone and HL5 = 2-benzoylpyridine N(4)-phenylthiosemicarbazone, have been synthesized. The complexes 1, 2,5 and 6 were characterized by elemental analysis, IR spectra and single-crystal X-ray diffraction studies. Preliminary in vitro screening indicated that all the tested compounds showed significant antitumor activity against K562 leucocythemia cancer cell line. (C) 2010 Elsevier Masson SAS. All rights reserved.