期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 45, 期 12, 页码 5646-5652出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2010.09.018
关键词
Known drug space; Marketed drug compounds; Drug-like chemical space; Natural products; Natural derivatives; Semi-synthetic drugs; Synthetic drugs; Molecular descriptors and drug development/discovery
Known drug space (KDS) was analysed for the occurrence of natural products and their derivatives. A database of 1000 marketed drugs was compiled. It was found that 10% of the drugs on the market are unaltered natural products, 29% are their derivatives (semi-synthetics) and the rest (61%) have a synthetic origin. Of the natural products, and their derivatives, polycyclic drugs were the most abundant at 21% followed by simple drugs (16%) and steroids (15%). In regard to the molecular descriptors the natural products had larger statistical means and standard deviations than their synthetic counterparts. It was found that KDS occupies a larger volume in chemical space with respect to drug-like chemicals, i.e., KDS fully encompasses drug-like chemical space with the parameters of molecular weight <= 800 g mol(-1), log P <= 6.5, hydrogen bond acceptors <= 15, hydrogen bond donors <= 7, polar surface area <= 180 angstrom(2), and rotatable bonds <= 17. Only 13% of the drugs analysed are outside one or more of these parameters. The definition of KDS gives drug designers a larger volume to work in compared to drug-like chemical space. However, the bulk of known drugs are found within the volume of drug-like chemical space. (C) 2010 Elsevier Masson SAS. All rights reserved.
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