期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 45, 期 1, 页码 142-148出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2009.09.036
关键词
1,2,3-Triazoles; [3+2] cycloaddition; Cuprous iodide; Antitubercular agents
资金
- UGC
- CSIR New Delhi
- DRDO
- DBT New Delhi
1,4-Disubstituted-1,2,3-triazoles (3-27) have been synthesized by [3+2] cycloaddition of different 2-(azidomethyl)-dihydronaptho(benzo)furans (2a, 2b, 2c and 2d) with different alkynes. All the compounds were screened for antitubercular activity against Mycobacterium tuberculosis H(37)Rv. Compounds 2a, 7,9,12 and 14 exhibited antitubercular activities with MIC ranging from 12.5 to 3.12 mu g/ml. (C) 2009 Elsevier Masson SAS. All rights reserved.
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