期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 45, 期 11, 页码 5251-5257出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2010.08.044
关键词
Dihydronaphtho[2,1-b]thiophene; Naphtho[2,1-b]thiophene; Thieno[2,3-d]pyrimidine; S-alkyl derivatives; Anti-avian influenza virus (H5N1)
资金
- Deutsche Forschungsgemeinschaft (DFG)
- Chemnitz University of Technology, Germany
Several derivatives containing dihydronaphtho, naphtho[2,1-b]thiophene and thieno[2,3-d]pyrimidine ring systems were prepared starting from 2-amino-4,5-dihydronaphtho[2,1-b]thiophene-1-carbonitrile (1). Structure characterization of the thioxo derivative 7 was also performed and its reaction with some chloro and bromoalkyl reagents was studied. Moreover, the prepared products were tested for antiviral activity against H5N1 virus [A/chicken/Egypt/1/2006 (H5N1)] by determination of both EC50 and LD50 and confirmed by plaque reduction assay on MDCK cells. Compounds 5, 7 and 8 showed the highest effect compared with the other tested compounds. (C) 2010 Elsevier Masson SAS. All rights reserved.
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