期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 45, 期 12, 页码 5979-5984出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2010.09.064
关键词
Butyrolactones; 2(5H)-furanone; Cytotoxic activity; Breast cancer
资金
- Iran National Science Foundation (INSF)
A series of dibenzyl-gamma-butyrolactones bearing a hydroxyl group at the benzylic position of 3-benzyl group were synthesized as hydrated analogue of isochaihulactone and evaluated against breast cancer human cell lines (MDA-M231, MCF-7 and T47D). The target compounds were synthesized in 7 steps from known lactone; (S)-(+)-gamma-benzyloxymethyl-gamma-butyrolactone. The key step was the aldol condensation between (+)-(R)-beta-(benzo[d][1,3]dioxol-5-ylmethyl)-gamma-butyrolactone and substituted benzaldehydes which afforded corresponding alpha-hydroxybenzyl butyrolactone analogues. The cytotoxic study of the synthesized compounds against breast cancer human cell lines showed that some of them inhibit breast cancer human cell proliferation with percentage inhibitions over 50% at concentrations less than 50 mu g/mL (C) 2010 Elsevier Masson SAS. All rights reserved.
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