期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 45, 期 2, 页码 738-744出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2009.11.021
关键词
Quinoline; Pyrimidoquinoline; Sulfonamide; Antitumor activity
Some novel quinolines and pyrimido[4,5-b]quinolines have been synthesized. The structures of which were confirmed by elemental analyses and spectral data. All the target compounds were subjected to in-vitro antitumor activity against Ehrlich Ascites Carcinoma (EAC) cells. Compounds 24,19 and 12 showed higher activity with IC50 values (5.5, 6.9, 7 mu g/ml) when compared with Doxorubicin as a reference drug (IC50 value 38 mu g/ml). (C) 2009 Elsevier Masson SAS. All rights reserved.
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