Diorganotin(IV) derivatives of ONO tridentate Schiff base: Synthesis, crystal structure, in vitro antimicrobial, anti-leishmanial and DNA binding studies

Six new diorganotin(IV) derivatives of N'-(2-hydroxybenzylidene)formohydrazide (H2L) with general formula R2SnL, where R = Ph (1), Me (2), Bu (3), Oct (4), t-Bu (5), Et (6), and L = [OC6H4CHNNCHO] have been synthesized and characterized by different analytical techniques. Crystal structure of Me2SnL (2) authenticated distorted square-pyramidal geometry around the Sn atom. The CV and UV-Vis spectroscopic data indicated intercalation of complexes into DNA with binding affinity varying in the sequence: 3 (1.69 x 10(4) M-1) > 1 (1.10 x 10(4) M-1) > 2 (9.61 x 10(3) M-1). Some of these compounds were found to be good antibacterial, antifungal and leishmanicidal agents. (C) 2010 Elsevier Masson SAS. All rights reserved.