期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 45, 期 12, 页码 5541-5560出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2010.09.035
关键词
2-Azetidinone; beta-Lactam; Four membered heterocyclic ring; Biological activity
2-Azetidinone, a beta-lactam four member heterocyclic compound involved in research aimed to evaluate new products that possess interesting biological activities. These compounds reported for their antimicrobial and antifungal activities. Successful introduction of aztreonam as a potent inhibitor of cephalosporinase and ezetimibe as a cholesterol absorption inhibitor proved potential of 2-azetidinone moiety. Subsequently 2-azetidinones were highlighted as a potent mechanism based inhibitor of several enzymes like human tryptase, chymase, thrombin, leukocyte elastase, human cytomegalovirus protease and serine protease enzyme. These derivatives also known to possess antitubercular, anti-inflammatory, antitumor, anti-HIV, antiparkinsonian, antidiabetic and vasopressin Via antagonist activity. The present review article focuses on the pharmacological profile of 2-azetidinones with their potential activities. (C) 2010 Elsevier Masson SAS. All rights reserved.
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