期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 45, 期 5, 页码 1772-1776出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2010.01.009
关键词
Pyrazol-5-ones; Acridine; Oxadiazole; Anti-inflammatory activity; Analgesic activity
A rapid preparation of compounds (1-24), with the objective of discovering novel and potent anti-inflammatory agent. All the compounds exhibited anti-inflammatory and analgesic activities at the dose 50 mg/kg p.o. The compound 1-(2',4'-Chloroacridine-9'-yl)-3-(5'-pyridine-4-yl)-(1,3,4-oxadiazol-2-yl-thiomethyl)-pyrazole-5-one 24 showed better anti-inflammatory and analgesic activities at the three graded dose of 25, 50 and 100 mg/kg p.o. (C) 2010 Elsevier Masson SAS. All rights reserved.
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