期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 45, 期 2, 页码 598-601出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2009.10.049
关键词
Antimycobacterial agents; Mycobacterium tuberculosis; REMA; Ruthenium (II) Complexes; Phosphines; Picolinate
资金
- CNPq
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2008/10390-2, 2009/06499-1]
- CYTED-RIIDFCM
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [08/10390-2] Funding Source: FAPESP
The synthesis, characterization and the anti-Mycobacterium tuberculosis (MTB) activities of three ruthenium complexes containing the 2-pyridinecarboxylic acid anion (picolinate), with formulae cis-[Ru(pic)(dppm)(2)]PF6 (1), Cis- [Ru(pic)(dppe)(2)]PF6 (2) and [Ru(pic)(2)(PPh3)(2)] (3) [pic = 2-pyridinecarboxylate; dppm = bis(diphenylphosphino)methane: dppe = 1,2-bis(diphenylphosphino)ethane; PPh3 = triphenylphosphine] are reported in this article. The complexes were characterized by elemental analysis, spectroscopic and electrochemical techniques. Their in vitro anti mycobacterial activity was determinated as the Minimum Inhibitory Concentration (MIC) for MTB cell growth, measured by the REMA method. The best MICs were found for complexes (1) and (2), with values of 0.78 and 0.26 mu g/mL, respectively. The results are comparable to or better than first line or second line drugs commonly used in the treatment of TB. (C) 2009 Elsevier Masson SAS. All rights reserved.
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