期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 44, 期 9, 页码 3697-3702出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2009.03.044
关键词
Ibuprofen; Schiff base; Mannich base; Anti-inflammatory agents; Analgesic agents
资金
- KSCSTE, Trivandrum
A series of 4-[(4-aryl)methylidene]amino-2-(substituted4-ylmethyl)-5-{1-[4-(2-methylpropyl)phenyl]ethyl}-2,4-dihydro-3H-1,2,4-triazole-3-thione (6) were synthesized from an arylpropionic acid namely, ibuprofen by a three-component Mannich reaction. Aminomethylation of 4-[(4-aryl)methylidenelamino-5-{1-[4-(2-methylpropyl)phenyl]ethyl}-4H-1,2,4-triazole-3-thiol (5) with formaldehyde and a secondary amine furnished this novel series of Mannich bases (6). Both Schiff bases (5) and Mannich bases (6) were well characterized on the basis of IR, NMR, mass spectral data and elemental analysis. They were screened for their anti-inflammatory, analgesic, antibacterial and antifungal activities. Some of the Mannich bases (6) carrying morpholino and N-methylpiperazino residues were found to be promising anti-inflammatory and analgesic agents. (C) 2009 Elsevier Masson SAS. All rights reserved.
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