期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 44, 期 6, 页码 2632-2635出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2008.09.029
关键词
Benzofuran; Nitromethane; Thiazolyl-pyrazoline; Antimicrobial activity
2-Acetylbenzofuran 1 on treatment with substituted aldehydes affords the corresponding chalcones 2a-c. Treatment of the chalcones with nitromethane under Michael addition condition furnished the corresponding Michael adducts 3a-c. Cyclocondensation of the chalcones 2a and 2b with thiosemicarbazide under basic refluxing conditions gave 3-(benzofuran-2-yl)-5-(4-aryl)-4,5-dihydropyrazole-1-carbothioamides 4a,b. The pyrazolines 7a-d were synthesized by treating 4a,b with phenacyl bromides in refluxing ethanol. All the synthesized compounds were screened for their antibacterial and antifungal activities at 100 mu g concentration. Some of our compounds showed excellent antimicrobial activities than control drugs. (C) 2008 Elsevier Masson SAS. All rights reserved.
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