期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 44, 期 12, 页码 4970-4977出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2009.08.011
关键词
Alkylphosphocholines; Antifungal activity; Antiprotozoal activity; Cytotoxic activity; Haemolytic activity; Quaternary ammonium compounds
资金
- [UK/110/2008]
- [VEGA 1/4300/07]
- [VEGA 1/3416/06]
- [VEGA1/4290/07]
- [VEGA 1/0164/08]
- [VEGA 1/4341/07]
A series of dialkylamino and nitrogen heterocyclic analogues of hexadecylphosphocholine and cetyltrimethylammonium bromide have been synthesized. The prepared compounds exhibit significant cytotoxic, antifungal and antiprotozoal activities. Alkylphosphocholines possess higher antifungal activity against Candida albicans in comparison with quaternary ammonium compounds. However, quaternary ammonium compounds exhibit significant higher activity against human tumor cells and Acanthamoeba lugdunensis compared to alkylphosphocholines. In addition, their haemolytic toxicity has been investigated. The relationship between structure and biological activity of the tested compounds is discussed. (C) 2009 Elsevier Masson SAS. All rights reserved.
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