期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 44, 期 9, 页码 3373-3387出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2009.05.013
关键词
Alkaloids; Aziridine; Synthesis; Anticancer; Antibacterial; Pharmacological activity; Micro-organisms; Plants; Invertebrates
The present review describes research on natural aziridine alkaloids isolated from both terrestrial and marine species, as well as their lipophilic semi-synthetic, and/or synthetic analogs. Over 130 biologically active aziridine-containing compounds demonstrate confirmed pharmacological activity including antitumor, antimicrobial, antibacterial effects. The structures, origin, and biological activities of aziridine alkaloids are reviewed. Consequently this review emphasizes the role of aziridine alkaloids as an important source of drug prototypes and leads for drug discovery. (C) 2009 Elsevier Masson SAS. All rights reserved.
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