期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 44, 期 11, 页码 4448-4454出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2009.06.003
关键词
Phthalazine; Coumarine; Triazine; Triazepine; Ketene N,S-acetal; Ketene S,S-diacetal; Bacillus thuringiensis; Escherichia coli
3-(1,4-Dioxo-3,4,4e,5,10,10a-hexahydro-1H-5,10-benzeno-benzo[g]phthalazin-2-yl)-3-oxo-propiononitrile (1) was utilized as key intermediate for the synthesis of some new iminocoumarin 2, chromenone 3, aminothiazole 4, triazepine 5a, b and 6, hydrazono-propiononitrile 7, pyridopyrazotriazine 8, monobromo 9, dibromo 10 quinoxaline 11, ketene N,S-acetal 13, ketene S,S-diacetal 17 and 18a, b and methyl dithioate 20 derivatives, respectively. The newly synthesized compounds were characterized by IR, H-1 NMR, C-13 NMR and mass spectral studies. Representative compounds of the synthesized product were tested and evaluated as antibacterial agent. (C) 2009 Elsevier Masson SAS. All rights reserved.
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