Regioselective synthesis and antimicrobial screening of novel ketocarbazolodispiropyrrolidine derivatives

A series of novel dispiropyrrolidine derivatives have been synthesized through 1,3-dipolar cycloaddition reaction of azomethine ylide generated from sarrosin and di/tri ketone with the dipolarophile (E)-2-arylidine-1-keto-carbazoles. The cycloadducts ketocarbazalo spiro N-methyl pyrrolidines showed the most interesting antimicrobial activity at lower concentration. (C) 2008 Elsevier Masson SAS. All rights reserved.