期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 44, 期 7, 页码 3020-3026出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2008.12.027
关键词
Coumarins; Lipoic acid; Antioxidant; Anti-inflammatory
In the present work a series of novel coumarin-3-carboxamides and their hybrids with the alpha-lipoic acid were designed, synthesized and tested as potent antioxidant and anti-inflammatory agents. The new compounds were evaluated for their antioxidant activity, their activity to inhibit in vitro lipoxygenase and their in vivo anti-inflammatory activity. In general, the derivatives were generally found to present antioxidant and anti-inflammatory activities. Discussion is made based on the results for the structure-activity relationships in order to define the structural features required for activity. (C) 2009 Elsevier Masson SAS. All rights reserved.
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