期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 44, 期 11, 页码 4668-4673出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2009.07.001
关键词
Flavonoid; Insulin; Diabetes; Glycogen synthesis
资金
- Conselho Nacional de Desenvolvimento e Tecnologico (CNPq)
- Coordenacao de Pessoal de Nivel Superior (CAPES-PGFAR)
- Fundacao de Amparo A Pesquisa do Estado de Santa Catarina (FAPESC)
In vivo and in vitro treatments were carried out to investigate the effects of apigenin-6-C-beta-L-fucopyranoside (1), isolated from Averrhoa carambola L. (Oxalidaceae), on serum glucose and insulin levels in hyperglycemic rats as well as its effect on glycogen synthesis in normal rat soleus muscle. Apigenin-6-C-beta-L-fucopyranoside showed an acute effect on blood glucose lowering in hyperglycemic rats and stimulated glucose-induced insulin secretion. A stimulatory effect of I on glycogen synthesis was observed when muscles were incubated with this flavonoid and also its effect was completely nullified by pre-treatment with insulin signal transduction inhibitors. Taking this into account, the MAPK-PPI and PI3K-GSK3 pathways are involved in the apigenin-6-C-beta-L-fucopyranoside-induced increase in glycogen synthesis in muscle. This study provides evidence for dual effects of apigenin-6-C-beta-L-fucopyranoside as an anti-hyperglycemic (insulin secretion) as well as an insulinomimetic (glycogen synthesis) agent. (C) 2009 Elsevier Masson SAS. All rights reserved.
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