期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 44, 期 7, 页码 3083-3089出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2008.07.003
关键词
4-Substituted-1,2,4-triazole-3-thiones; Mannich bases; (Phenylsulfonyl)phenyl moiety; Antibacterial activity
A series of Mannich bases of 4-substituted 5-[4-(4-X-phenyisulfonyl)phenyl]-2,4-dihydro-3H-1,2,4-triazole-3-thiones, X = H, Cl, Br, 3 and 5 were synthesized and characterized on the basis of IR, NMR and elemental analyses. The potential antibacterial effects of the synthesized compounds were investigated using the Acinetobacter baumanii ATCC 19606; Citrobacter freundii ATCC 8090; Pseudomonas aeruginosa ATCC 9027; Enterococcus faecalis ATCC 19433; Staphylococcus aureus ATCC 12600; Staphylococcus epidermidis ATCC 14990; Bacillus subtilis ATCC 6633 strains. Some of them exhibited promising activities against A. baumanii and B. subtilis. (C) 2008 Elsevier Masson SAS. All rights reserved.
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