期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 43, 期 8, 页码 1767-1773出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2007.10.023
关键词
thiosemicarbazones derived from 1-indanones; antiviral activity
资金
- University of Buenos Aires UBACYT (2004-2007) [B008, B016, B033, B036]
Identification of new therapeutic agents for the treatment of viral diseases represents an area of active investigation. In an effort to develop new antiviral compounds, a series of 1-indanone thiosemicarbazone derivatives were synthesized. These derivatives were structurally characterized using several spectroscopic techniques and evaluated against bovine viral diarrhoea virus as a surrogate model for hepatitis C virus. Thiosemicarbazone 2m showed potent anti-bovine viral diarrhoea virus activity with a higher selectivity index (SI = 80.29) than that of ribavirin (SI = 11.64). This result determines the potentiality of these thiosemicarbazones as antiviral agents for the treatment of infections caused by other highly related members of Flaviviridae family, as hepatitis C virus. (c) 2007 Elsevier Masson SAS. All rights reserved.
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