期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 43, 期 2, 页码 309-314出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2007.03.024
关键词
2,4-dichloro-5-fluorophenyl triazole; intramolecular cyclization; aminotriazolothiadiazines; antimicrobial activity
Dichlorofluorophenyl containing aminotriazolothiadiazines (6) were synthesized by initial condensation of 2-chloro-N-(substituted phenyl) acetamides (4) with triazole (3) and further cyclization using POCl3. The structures of newly synthesized compounds were confirmed by IR, NMR, mass and elemental analysis. All the compounds were screened for their antibacterial and antifungal activities. Compounds 5a, 5e, 5n, 5o, 6a, 6n, and 6o showed very good antibacterial and antifungal activities at 6.25 mu g/ml concentrations. (c) 2007 Elsevier Masson SAS. All rights reserved.
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