期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 43, 期 10, 页码 2178-2188出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2007.08.007
关键词
Fluorinated coumarin; Fluorinated 1-aza coumarin; Anti-bacterial; Anti-fungal; Analgesic; Anti-inflammatory
资金
- Karnatak University and Karnatak Science College, Dharwad
A series of new fluorinated coumarins and 1-aza coumarins have been synthesized and the presence of fluorine in these molecules and its effect on their anti-microbial, anti-inflammatory and analgesic activities are discussed. The results of bioassay showed that these newly synthesized compounds containing fluorine exhibit moderate analgesic and excellent anti-inflammatory and potential anti-bacterial and anti-fungal activities, compared to the other halogenated compounds. All the newly synthesized compounds were characterized by elemental analysis, IR, H-1 NMR, C-13 NMR, F-19 NMR, EI-MS, and FAB-MS. The ORTEP diagram of one of the compounds is reported herein. (C) 2007 Elsevier Masson SAS. All rights reserved.
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