期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 43, 期 8, 页码 1791-1795出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2007.09.030
关键词
poly(amidoamine) dendrimers; PAMAM; drug carrier; anti-cancer drugs; camptothecin; solubility
资金
- Natural Science Foundation of Anhui Province [070413112]
- Hefei National Laboratory for Physical Sciences at Microscale [C07-06]
- Graduate Student in University of Science and Technology of China [KD2004035]
Camptothecin (CPT), a plant alkaloid isolated from Camptotheca acuminata, has an extremely low solubility in aqueous medium, which presents a major challenge during drug formulation in clinical trails. In the present study we investigated the potential of poly(amidoamine) (PAMAM) dendrimers as drug carriers of CPT through aqueous solubility studies. Results showed that the aqueous solubility of CPT was significantly increased by PAMAM dendrimers. The effect of PAMAM generation on CPT solubility was also evaluated. These studies indicated that PAMAM dendrimers might be considered as biocompatible carriers of CPT. (C) 2007 Elsevier Masson SAS. All rights reserved.
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