期刊
EUROPEAN JOURNAL OF MEDICAL GENETICS
卷 51, 期 4, 页码 322-324出版社
ELSEVIER
DOI: 10.1016/j.ejmg.2008.05.001
关键词
Silver-Russell syndrome; isolated imprinting mutations; PEG1/MEST; methylation-specific PCR
资金
- NovoNordisk GmbH
- RWTH Aachen (N.S.)
Imprinting defects have meanwhile been described in nearly all human imprinting disorders among them Silver-Russell syndrome (SRS). In this disorder, 11p15 epimutations and maternal Uniparental Disomy of chromosome 7 (UPD7) are detectable in similar to 50% of patients. To find out whether isolated imprinting defects on chromosome 7 play a role in the aetiology of SRS we screened a cohort of 54 SRS patients without 11p15 epimutations. Methylation-specific PCR was carried out for the PEG1/MEST locus in 7q31. This test detects all known segmental and complete UPD7 cases. The exclusion of isolated imprinting defects in our study population shows that this type of epimutation at the PEG1/MEST locus in 7q31 does not play a relevant role in SRS. However, the role of imprinting disturbances in other genes cannot be excluded. (C) 2008 Elsevier Masson SAS. All rights reserved.
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