期刊
EUROPEAN JOURNAL OF MASS SPECTROMETRY
卷 14, 期 3, 页码 163-170出版社
SAGE PUBLICATIONS LTD
DOI: 10.1255/ejms.924
关键词
sport; doping; mass spectrometry; SARM; Ostarine
资金
- Manfred-Donike Institute for Doping Analysis, Cologne
- Fonds der Chemischen Industrie, Frankfurt
The elucidation of the metabolism of new therapeutics is a major task for pharmaceutical companies and of great interest for drug testing Laboratories. The tatter in particular need to determine the presence or absence of drugs or their metabolic products in urine to test for a misuse of these compounds. Commonly, in vitro or animal models are used to mimic the human metabolism and produce potential targets in amounts allowing for method development. An alternative route based on electrochemical reactions of drugs was reported to allow for the generation of selected metabolites. The utility of this approach for doping control purposes was demonstrated with a novel class of anabolic agents termed selective androgen receptor modulators (SARMs). An arylpropionamide-derived drug candidate was subjected to etectrochemical metabolism and a major phase-I-metabolite, resulting from the elimination of a substituted phenol residue as identified in in vitro experiments, was generated and characterised using liquid chromatography/nuclear magnetic resonance spectroscopy and high resolution/high accuracy mass spectrometry. The metabolite was included in routine doping control procedures based on Liquid chromatography/tandem mass spectrometry and has served as a reference compound for 5000 doping control specimens.
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