期刊
ACS NANO
卷 9, 期 11, 页码 11455-11461出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.5b05575
关键词
carbon dots; full-color emission; targeted imaging; brain cancer glioma; diagnosis
类别
资金
- National Natural Science Foundation of China [51522307, 91227118, 21201159, 61176016]
- Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry
- CAS
- Innovation and Entrepreneurship Program of Jilin
- CIAC
A new type of carbon dots (CD-Asp) with targeting function toward brain cancer glioma was synthesized via a straightforward pyrolysis route by using a-glucose and L-aspartic acid as starting materials. The as-prepared CD-Asp exhibits not only excellent biocompatibility and tunable full-color emission, but also significant capability of targeting C6 glioma cells without the aid of any extra targeting molecules. In vivo fluorescence images showed high-contrast biodistribution of CD-Asp 15 min after tail vein injection. A much stronger fluorescent signal was detected in the glioma site than that in normal brain, indicating their ability to freely penetrate the blood brain barrier and precisely targeting glioma tissue. However, its counterparts, the CDs synthesized from a-glucose (CD-G), L-asparic acid (CD-A), or D-glucose and L-glutannic acid (CD-Glu) have no or low selectivity for glioma. Therefore, CD-Asp could act as a fluorescence imaging and targeting agent for noninvasive glioma diagnosis. This work highlights the potential application of CDs for constructing an intelligent nanomedicine with integration of diagnostic, targeting, and therapeutic functions.
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