期刊
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
卷 -, 期 34, 页码 5854-5861出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejic.201300809
关键词
Mercury; Sensors; Logic gates; Cell-imaging; Fluorescence
资金
- Department of Science and Technology (DST), Government of India, New Delhi [SR/S1/IC-20/2012]
- Council of Scientific and Industrial Research (CSIR), New Delhi [01(2490)/11/EMR-II]
- University Grants Commission (UGC), New Delhi (UGC-NET)
- DST through the PURSE Program
A new rhodamine-based dual signaling probe (L-3) has been found to display quick responses through visible colorimetric changes as well as fluorogenic properties on selective 1:1. binding to Hg2+, as delineated by absorption and :fluorescence titrations as well as by Job's method and ESI-MS+ studies. The fluorescent probe L-3 displays a 252-fold fluorescence enhancement on binding to Hg2+. A Benesi-Hilderband fit of the absorption titration data gives K-d = (32.01 +/- 0.74) mu m and a 1:1 binding stoichiometry. Owing its solubility in mixed organic/aqueous solvents as well as its cell permeability, L-3 could be used for in vitro/in vivo cell imaging of Hg2+ with no or negligible cytotoxicity. The detection limit of Hg2+ was calculated by the 3 sigma method to be 9.28 ng L-1. Moreover, the fluorescence of the L-3-Hg2+ system was turned off and its red colour disappeared when KI was added. Thus, the OFF-ON-OFF fluorescence sensing behaviour of L-3 observed in the presence of Hg2+ and I may.find applications in devices with logic gate functions.
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