期刊
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
卷 -, 期 12, 页码 1924-1933出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejic.201101137
关键词
Imaging agents; Nanoparticles; Chelates; MRI contrast agent; Blood-pool agent; Targeting agent; Gadolinium
资金
- Ministry of Commerce, Industry, and Energy
- ROK [RTI04-01-01]
- National Research Foundation (NRF) [2010-0002436, 2011-0015353, 2010-0024143]
- National Research Foundation of Korea [2010-0002436, 2010-0024143, 과06B1508, 2011-0015353] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Magnetic resonance imaging (MRI) is a powerful and noninvasive diagnostic technique of the human anatomy, physiology, and pathophysiology on the basis of superior spatial resolution and contrast. MRI is useful in providing anatomical and functional images of the human body. A large number of MRI techniques are performed employing gadolinium III [GdIII] complexes to enhance image contrast by increasing the water proton relaxation rate in the body. Despite their wide and successful application in clinic, however, conventional GdIII-based low-molecular weight contrast agents (CAs) are mostly extracellular contrast agents (ECCAs) exhibiting rapid extravasation from the vascular space. As a result, the time window for imaging is considerably reduced, thus limiting acquisition of high-resolution images. To overcome such limitations inherent to ECCAs, the necessity and the demand for the development of a new class of MRI CAs with functions including blood-pool and organ (or tumor)-targeting have risen recently. This microreview deals with our recent efforts on the design and the synthesis of new Gd-chelates and Gd nanoparticles (GdNPs) for use as blood-pool and organ/tumor-targeting MRI CAs. We also consider properties such as high r1 relaxivity and high thermodynamic, kinetic, and biostabilities.
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