期刊
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
卷 -, 期 20, 页码 3050-3058出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejic.201100125
关键词
Chemosensors; Zinc; Density functional calculations; Fluorescent probes; Bioinorganic chemistry
资金
- Department of Science and Technology
- Council of Scientific and Industrial Research (CSIR), India
- CSIR
- University Grants Commission (UGC), New Delhi
- Department of Bio Technology (DBT), India
A new Zn-II-2,2':6',2 ''-terpyridine complex, derivatized with a coumarin moiety (L1Zn), acts as a fluorescent chemosensor for different biologically important phosphates like PPi, AMP and ADP in mixed aqueous media. Depending on the proportion of the aqueous fraction present in the solvent mixture, L1Zn shows a preference for different phosphate moieties at physiological pH. In an aqueous acetonitrile (2:3, v/v) medium this reagent shows a preference for AMP as compared to ADP, ATP and PPi. The binding affinities of L1Zn with different phosphate ions and associated shifts in the electronic spectra were rationalized by DFT calculations. Such an example of a receptor that is selective for AMP under physiological conditions is rare in the literature.
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