期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 44, 期 2, 页码 321-327出版社
WILEY-BLACKWELL
DOI: 10.1002/eji.201344135
关键词
Cancer; Immune regulation; Immune responses; Inflammation; Innate immunity
类别
资金
- American Cancer Society
- National Institutes of Health [R01 CA166879]
- GI SPORE Developmental Research Project Grant
There has been significant interest in understanding how interactions between the host immune system and the gut microbiota regulate intestinal homeostasis. Recent data suggest that the Nod-like receptor (NLR) family of PRRs regulate both the composition of the gut microbiota and innate immune signaling pathways that prevent pathologic intestinal inflammation and tumorigenesis. In this review, we will focus on NLRP6 and NLRP12, two members of the NLR family that have emerged as important players in the maintenance of intestinal homeostasis, and discuss the signaling pathways engaged by these receptors as well as the current models of how these receptors protect against the development of colitis and tumorigenesis.
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