期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 43, 期 10, 页码 2566-2576出版社
WILEY
DOI: 10.1002/eji.201243066
关键词
Antigen presentation; processing; Cross-presentation; priming; Immunopathology; Infectious diseases; Innate immunity
类别
资金
- Deutsche Forschungsgemeinschaft [GraKo 1121]
- Charite-Universitatsmedizin Berlin
Hantaviruses are emerging human pathogens. They induce an unusually strong antiviral response of human HLA class I (HLA-I) restricted CD8(+) T cells that may contribute to tissue damage and hantavirus-associated disease. In this study, we analyzed possible hantaviral mechanisms that enhance the HLA-I antigen presentation machinery. Upon hantavirus infection of various human and primate cell lines, we observed transactivation of promoters controlling classical HLA molecules. Hantavirus-induced HLA-I upregulation required proteasomal activity and was associated with increased TAP expression. Intriguingly, human DCs acquired the capacity to cross-present antigen upon hantavirus infection. Furthermore, knockdown of TIR domain containing adaptor inducing IFN- or retinoic acid inducible gene I abolished hantavirus-driven HLA-I induction. In contrast, MyD88-dependent viral sensors were not involved in HLA-I induction. Our results show that hantaviruses strongly boost the HLA-I antigen presentation machinery by mechanisms that are dependent on both retinoic acid inducible gene I and TIR domain containing adaptor inducing IFN-beta.
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