期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 43, 期 11, 页码 3017-3027出版社
WILEY
DOI: 10.1002/eji.201343627
关键词
CD28; Innate-like CD8 T cells; NKT cells; PLZF; Thymocyte development
类别
资金
- Canadian Institutes of Health Research (CIHR)
- Fondation Armand-Frappier
NK T cells(NKT cells) share functional characteristics and homing properties that are distinct from conventional T cells. In this study, we investigated the contribution of CD28 in the functional development of NKT and NKT cells in mice. We show that CD28 promotes the thymic maturation of promyelocytic leukemia zinc finger(+) IL-4(+) NKT cells and upregulation of LFA-1 expression on NKT cells. We demonstrate that the developmental defect of NKT cells in CD28-deficient mice is cell autonomous. Moreover, we show in both wild-type C57BL/6 mice and in downstream of tyrosine kinase-1 transgenic mice, a mouse model with increased numbers of NKT cells, that CD28-mediated regulation of thymic IL-4(+) NKT cells promotes the differentiation of eomesodermin(+) CD44(high) innate-like CD8(+) T cells. These findings reveal a previously unappreciated mechanism by which CD28 controls NKT-cell homeostasis and the size of the innate-like CD8(+) T-cell pool.
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