期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 42, 期 4, 页码 982-992出版社
WILEY
DOI: 10.1002/eji.201141519
关键词
B1 cells; B cells; BCR; Phagocytosis; Staphylococcus aureus
类别
资金
- National Natural Science Foundation of China [30771949, 31070793, 30872299, 30972641]
B1 cells are evolutionarily conserved innate-like cells that share many features with macrophages. It has also been established that B1 cells have a close developmental relationship with macrophages. However, whether B1 cells are able to act as professional phagocytic cells is not clear. In this study, we report that mouse peritoneal cavity (PerC) B cells demonstrate in vivo and in vitro phagocytic activities for Staphylococcus aureus, Escherichia coli, and polystyrene fluorescent microspheres. Approximately 5% of PerC B cells, mainly B1b cells, showed phagocytic activity. Ingested microbes were killed efficiently in the phagolysosome. The antigen-specific B-cell antigen receptor promoted B-cell phagocytosis, resulting in antigen presentation to T cells after uptake of bacteria. Our results reveal for the first time that mouse B1 cells have active phagocytic capabilities and thereby act as a bridge linking innate and adaptive immunity.
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