期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 41, 期 3, 页码 602-610出版社
WILEY
DOI: 10.1002/eji.201041211
关键词
CD1 molecules; Cellular immunology; Immune response; T cells
类别
资金
- Italian Association for Cancer Research [AIRC-5804]
- International Association for Cancer Research (AICR)
- Italian Ministry of Health Programma Straordinario Ricerca Oncologica [RFPS-2006-4-341763]
- Swiss National Fund [3100A0-122464/1]
- University of Vita-Salute San Raffaele (Milano, Italy)
CD1 molecules present lipid antigens to T cells. An intriguing subset of human T cells recognize CD1-expressing cells without deliberately added lipids. Frequency, subset distribution, clonal composition, naive-to-memory dynamic transition of these CD1 self-reactive T cells remain largely unknown. By screening libraries of T-cell clones, generated from CD4(+) or CD4(-)CD8(-) double negative (DN) T cells sorted from the same donors, and by limiting dilution analysis, we find that the frequency of CD1 self-reactive T cells is unexpectedly high in both T-cell subsets, in the range of 1/10-1/300 circulating T cells. These T cells predominantly recognize CD1a and CD1c and express diverse TCRs. Frequency comparisons of T-cell clones from sorted naive and memory compartments of umbilical cord and adult blood show that CD1 self-reactive T cells are naive at birth and undergo an age-dependent increase in the memory compartment, suggesting a naive/memory adaptive-like population dynamics. CD1 self-reactive clones exhibit mostly Th1 and Th0 functional activities, depending on the subset and on the CD1 isotype restriction. These findings unveil the unanticipated relevance of self-lipid T-cell response in humans and clarify the basic parameters of the lipid-specific T-cell physiology.
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