期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 41, 期 4, 页码 889-897出版社
WILEY
DOI: 10.1002/eji.201041340
关键词
Lysosomal targeting; Opsonization; T-cell response
类别
资金
- Roche Research Fund for Biology
- Bonizzi-Theler Stiftung
- GEBERT-RUF-STIFTUNG
- Swiss National Science Foundation
- Vontobel Foundation
- UBS AG
Intracellular pathogen-specific antibodies (Abs) can contribute to host protection by a number of different mechanisms. Ab opsonization of pathogens residing outside a host cell can prevent infection of target cells either via neutralization of the critical surface epitopes required for host cell entry, complement-mediated degradation, or via subsequent intracellular degradation. In the case of intracellular localization, Abs can bind to infected cells and thus mark them for destruction by Fc receptor (FcR)-bearing effector cells. This review focuses on the protective role of Abs against intracellular bacteria and parasites involving FcR interactions that modulate the intracellular trafficking of the pathogen, the ability of FcRs to interfere with the establishment of an intracellular replicative niche and the involvement of FcRs to modulate pathogen-specific T-cell responses.
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