期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 41, 期 6, 页码 1800-1808出版社
WILEY-BLACKWELL
DOI: 10.1002/eji.201041187
关键词
B-cell memory; Hepatitis B; Long-lived plasma cells; Serum antibodies; Vaccination
类别
资金
- AIFA (Agenzia Italiana del farmaco, Bando per la Ricerca Indipendente, anno)
- EUROPAD NET (EC) [201549]
The immunogenicity of a vaccine is conventionally measured through the level of serum Abs early after immunization, but to ensure protection specific Abs should bemaintained long after primary vaccination. For hepatitis B, protective levels often decline over time, but breakthrough infections do not seem to occur. The aim of this study was to demonstrate whether, after hepatitis B vaccination, B-cell memory persists even when serum Abs decline. We compared the frequency of anti-hepatitis-specific memory B cells that remain in the blood of 99 children five years after priming with Infanrix (R)-hexa (GlaxoSmithKline) (n=34) or with Hexavac (R) (Sanofi Pasteur MSD) (n=65). These two vaccines differ in their ability to generate protective levels of IgG. Children with serum Abs under the protective level, <10mIU/mL, received a booster dose of hepatitis B vaccine, and memory B cells and serum Abs were measured 2wk later. We found that specific memory B cells had a similar frequency in all children independently of primary vaccine. Booster injection resulted in the increase of memory B cell frequencies (from11.3 in 10(6) cells to 28.2 in 10(6) cells, p<0.01) and serumAbs (geometric mean concentration, GMC from 2.9 to 284mIU/mL), demonstrating that circulating memory B cells effectively respond to Ag challenge even when specific Abs fall under the protective threshold.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据