期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 41, 期 11, 页码 3125-3134出版社
WILEY
DOI: 10.1002/eji.201041092
关键词
ICOS/ICOSL pathway; Marginal zone B cells; NKT cells; Presentation of glycolipids; Splenic DCs
类别
资金
- Kultusministerium of Niedersachsen
- Marie Curie Action Miditrain [MEST-CT-2004-504990]
- Helmholtz Gemeinschaft via HIRSIB
- Deutsche Krebshilfe
- German Research Council (DFG)
- Emmy-Noether Program [KR2320/2-1, EXC62]
Marginal zone (MZ) B cells express high levels of CD1d molecules. In accordance, MZ B cells, like splenic conventional DCs (cDCs), efficiently trigger NKT-cell proliferation. Importantly, MZ B cells exclusively induced production of IL-4 and IL-13 by such cells whereas cDCs induced robust production of mainly IFN-gamma. NKT-cell proliferation, IL-4 and IL-13 production induced by MZ B cells were dependent on ICOS/ICOS ligand interaction while IFN-gamma and IL-17 induction by cDCs required glucocorticoid-induced TNF receptor/glucocorticoid-induced TNF receptor ligand interplay. Our data illustrate that both MZ B cells and cDCs act as efficient APCs for NKT cells and might differentially influence the quality of the subsequent immune response.
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