期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 41, 期 9, 页码 2612-2618出版社
WILEY-BLACKWELL
DOI: 10.1002/eji.201041075
关键词
CD8 T cells; Cellular immunology; Cross-presentation/priming; Immune evasion; Infectious diseases
类别
资金
- ETH Zurich
- Swiss National Science Foundation [310000-129751]
Priming of CD8(+) T cells specific for viruses that interfere with the MHC class I presentation pathway is a challenge for the immune system and is believed to rely on cross-presentation. Cytomegalovirus (CMV) infection induces vigorous CD8(+) T-cell responses despite its potent immune evasion strategies. Furthermore, CD8(+) T cells specific for a subset of viral epitopes accumulate and are maintained at high levels exhibiting an activated phenotype - referred to as inflationary T cells. Taking advantage Batf3(-/-) mice in which the development of cross-presenting CD8 alpha(+) and CD103(+) DCs is severely compromised, we analyzed their role in the induction and inflation of murine (M) CMV-specific CD8(+) T-cell responses. We found that priming of MCMV-specific CD8(+) T cells was severely impaired in the absence of cross-presenting DCs. However, inflation of two immuno-dominant MCMV-specific CD8(+) T-cell populations was largely normal in the absence of cross-presenting DCs, indicating that inflation during latency was mainly dependent on direct antigen presentation. These results highlight differential antigen presentation requirements during acute and latent MCMV infection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据