期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 40, 期 8, 页码 2200-2210出版社
WILEY
DOI: 10.1002/eji.201040433
关键词
Granulocytes; IL-10; IL-17; Mycobacterium tuberculosis; Th1
类别
资金
- MRC
- EU
- Medical Research Council [MC_U117565642] Funding Source: researchfish
- MRC [MC_U117565642] Funding Source: UKRI
IL-10 regulates the balance of an immune response between pathogen clearance and immunopathology. We show here that Mycobacterium tuberculosis (Mtb) infection in the absence of IL-10 (IL-10(-/-) mice) results in reduced bacterial loads in the lung. This reduction was preceded by an accelerated and enhanced IFN-gamma response in the lung, an increased influx of CD4(+) T cells into the lung, and enhanced production of chemokines and cytokines, including CXCL10 and IL-17, in both the lung and the serum. Neutralization of IL-17 affected neither the enhanced production of CXCL10 nor the accumulation of IFN-gamma-producing T cells in the lungs, but led to reduced numbers of granulocytes in the lung and reduced bacterial loads in the spleens of Mtb-infected mice. This suggests that IL-17 may contribute to dissemination of Mtb.
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