期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 40, 期 4, 页码 1073-1078出版社
WILEY
DOI: 10.1002/eji.200940041
关键词
Anti-inflammatory; cAMP; Defensin; TNF-alpha
类别
资金
- MRC
- EPSRC
- ARC
- Wellcome Trust [078265]
- MRC [MC_U127527201, MC_U127527200] Funding Source: UKRI
- Medical Research Council [MC_U127527201, MC_U127527200, G9900991B] Funding Source: researchfish
beta-defensins are antimicrobial peptides with an essential role in the innate immune response. In addition beta-defensins can also chemoattract cells involved in adaptive immunity. Until now, based on evidence from dendritic cell stimulation, human beta defensin-3 (hBD3) was considered pro-inflammatory. We present evidence here that hBD3 lacks pro-inflammatory activity in human and mouse primary M phi. In addition, in the presence of LPS, hBD3 and the murine orthologue Defb14 (but not hBD2), effectively inhibit TNF-alpha and IL-6 accumulation implying an anti-inflammatory function. hBD3 also inhibits CD40/IFN-gamma stimulation of M phi and in vivo, hBD3 significantly reduces the LPS-induced TNF-alpha level in serum. Recent work has revealed that hBD3 binds melanocortin receptors but we provide evidence that these are not involved in hBD3 immunomodulatory activity. This implies a dual role for hBD3 in antimicrobial activity and resolution of inflammation.
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