期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 40, 期 3, 页码 599-606出版社
WILEY
DOI: 10.1002/eji.201040319
关键词
Cytokines; Immunotherapy; Innate immunity; TLR
类别
资金
- NIH [AI-15614, CA-04 6934]
- JDRF [26-2008-893]
Although there has been a great amount of progress in the 25 years since the first reporting of the cDNA for IL-1 alpha and IL-1 beta, the history of IL-1 goes back to the early 1940s. In fact, the entire field of inflammatory cytokines, TLR and the innate immune response can be found in the story of IL-1. This Viewpoint follows the steps from the identification of the fever-inducing activities of soluble factors produced by endotoxin-stimulated leukocytes through to the discovery of cryopyrin and the caspase-1 inflammasome and on to the clinical benefits of anti-IL-1 beta-based therapeutics. It also discusses some of the current controversies regarding the activation of the inflammasome. The future of novel anti-inflammatory agents to combat chronic inflammation is based, in part, on the diseases that are uniquely responsive to anti-IL-1 beta, which is surely a reason to celebrate the 25th anniversary of the cloning of IL-1 alpha and IL-1 beta.
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