期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 40, 期 3, 页码 631-634出版社
WILEY
DOI: 10.1002/eji.200940162
关键词
Autoinflammatory; Cancer; Inflammasome; IL-1 inhibition; Liver
类别
资金
- Yorkshire Cancer Research
- NIHR-Leeds Musculoskeletal Biomedical Research Unit (LMBRU)
- The Royal Society
- FP7-HEALTH [2007-2.4.4-1]
- Charitable Foundation
- Arthritis Research Campaign (arc)
A role for NLRP3 inflammasome in recurrent and chronic inflammation was initially described in a group of rare autoinflammatory conditions, termed cryopyrin-associated periodic syndrome. Subsequently, inflammasomes have been implicated in the pathology of many common diseases, including cancer, gout and diabetes. Despite diverse pathologies, the central role of the inflammasome in innate defences and tumour elimination suggests common therapeutic approaches to reduce inflammation where appropriate.
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