期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 40, 期 9, 页码 2385-2390出版社
WILEY-BLACKWELL
DOI: 10.1002/eji.201040534
关键词
CD4(+) T cells; NKT cells; Thymic selection; Transcription
类别
资金
- National Cancer Institute, Center for Cancer Research, and of the National Institute of Allergy and Infectious Diseases, NIH
- NIH [R01 AI038339]
While most CD4(+) T cells are MHC class II-restricted, a small subset, including the CD1d-restricted 'invariant' NKT (iNKT) cells, are selected on non-classical MHC-I or MHC-I-like molecules. We previously showed that the sequential activity of two zinc finger transcription factors, Gata3 and Thpok, promotes the differentiation of conventional, MHC II-restricted thymocytes into CD4(+) T cells. In the current study, we show that a Gata3-Thpok cascade is required for the differentiation of CD4(+) iNKT cells. Gata3 is required for iNKT cells to express Thpok, whereas Thpok is needed for proper NKT cell differentiation, and notably for NKT cells to maintain CD4 and terminate CD8 expression. These findings identify the sequential activity of Gata3 and Thpok as a hallmark of CD4(+) T-cell differentiation, regardless of MHC restriction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据