期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 40, 期 10, 页码 2830-2836出版社
WILEY
DOI: 10.1002/eji.200940115
关键词
Human; Mucosal leishmaniasis; Neutrophils; Th17
类别
资金
- CNPq
- PRONEX [738712006]
- FAPESB
- FAPESP [2004/08-868-0]
- CAPES
Mucosal leishmaniasis (ML) is characterised by severe tissue destruction. Herein, we evaluated the involvement of the IL-17-type response in the inflammatory infiltrate of biopsy specimens from 17 ML patients. IL-17 and IL-17-inducing cytokines (IL-1 beta, IL-23, IL-6 and TGF-beta) were detected by immunohistochemistry in ML patients. IL-17(+) cells exhibited CD4(+), CD8(+) or CD14(+) phenotypes, and numerous IL-17(+) cells co-expressed the CC chemokine receptor 6 (CCR6). Neutrophils, a hallmark of Th17-mediated inflammation, were regularly detected in necrotic and perinecrotic areas and stained positive for neutrophil elastase, myeloperoxidase and MMP-9. Taken together, these observations demonstrate the existence of Th17 cells in ML lesions associated with neutrophils in areas of tissue injury and suggest that IL-17 is involved in ML pathogenesis.
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