期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 40, 期 3, 页码 607-611出版社
WILEY
DOI: 10.1002/eji.200940207
关键词
Caspase-1; Danger signals; Necrosis
类别
资金
- National Institutes of Health [K08 AI065517, K08 AI067736]
Through pattern recognition receptors the innate immune system detects disruption of the normal function of the organism and initiates responses directed at correcting these derangements. Cellular damage from microbial or non-microbial insults causes the activation of nucleotide-binding domain leucine-rich repeat containing receptors in multiprotein complexes called inflammasomes. Here we discuss the role of the NLRP3 inflammasome in the recognition of cellular damage and the initiation of sterile inflammatory responses.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据