期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 39, 期 1, 页码 207-215出版社
WILEY
DOI: 10.1002/eji.200838748
关键词
CD161; ROR gamma t; TGF-beta; Th17
类别
资金
- EU [FP6-LSBH-CT-2006-018861]
- INNOCHEM [FP6LSHB-CT-2005-518167]
Human Th17 clones and circulating Th17 cells showed lower susceptibility to the antiproliferative effect of TGF-beta than Th1 and Th2 clones or circulating Th1-oriented T cells, respectively. Accordingly, human Th17 cells exhibited lower expression of clusterin, and higher Bcl-2 expression and reduced apoptosis in the presence of TGF-beta, in comparison with Th1 cells. Umbilical cord blood naive CD161(+)CD4(+) T cells, which contain the precursors of human Th17 cells, differentiated into IL-17A-producing cells only in response to IL-1 beta plus IL-23, even in serum-free cultures. TGF-beta had no effect on constitutive ROR gamma t expression by umbilical cord blood CD161(+) T cells but it increased the relative proportions of CD161(+) T cells differentiating into Th17 cells in response to IL-1 beta plus IL-23, whereas under the same conditions it inhibited both T-bet expression and Th1 development. These data suggest that TGF-beta is not critical for the differentiation of human Th17 cells, but indirectly favors their expansion because Th17 cells are poorly susceptible to its suppressive effects.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据