期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 39, 期 11, 页码 2955-2965出版社
WILEY
DOI: 10.1002/eji.200939650
关键词
Cathepsins; Endosomes; Immune regulation; Lysosomes
类别
资金
- Wellcome Trust
- Medical Research Council
The innate and adaptive immune system utilise endocytic protease activity to promote functional immune responses. Cysteine and aspartic proteases (cathepsins) constitute a subset of endocytic proteases, the immune function of which has been described extensively. Although historically these studies have focused on their role in processes such as antigen presentation and zymogen processing within the endocytic compartment, recent discoveries have demonstrated a critical role for these proteases in other intracellular compartments, and within the extracellular milieu. It has also become clear that their pattern of expression and substrate specificities are more diverse than was first envisaged. Here, we discuss recent advances addressing the role of lysosomal proteases in various aspects of the immune response. We pay attention to reports demonstrating cathepsin activity outside of its canonical endosome/lysosome microenvironment.
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