期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 39, 期 7, 页码 1784-1793出版社
WILEY
DOI: 10.1002/eji.200839106
关键词
Bacterial infections; CD8(+) T cells; Cytokines; KO mice; Self/non-self discrimination
类别
资金
- Japan Society for Promotion of Science
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
IL-15 is a pleiotropic cytokine involved in host defense as well as autoimmunity. IL-15-deficient mice show a decrease of memory phenotype (MP) CD8(+) T cells, which develop naturally in naive mice and whose origin is unclear. It has been shown that self-specific CD8(+) T cells developed in male H-Y antigen-specific TCR transgenic mice share many similarities with naturally occurring MP CD8(+) T cells in normal mice. In this study, we found that H-Y antigen-specific CD8(+) T cells in male but not female mice decreased when they were crossed with IL-15-deficient mice, mainly due to impaired peripheral maintenance. The self-specific TCR transgenic CD8(+) T cells developed in IL-15-deficient mice showed altered surface phenotypes and reduced effector functions ex vivo. Bystander activation of the self-specific CD8(+) T cells was induced in vivo during infection with Listeria monocytogenes, in which proliferation but not IFN-gamma production was IL-15-dependent. These results indicated important roles for IL-15 in the maintenance and functions of self-specific CD8(+) T cells, which may be included in the naturally occurring MP CD8(+) T-cell population in naive normal mice and participate in innate host defense responses.
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