期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 38, 期 11, 页码 3159-3166出版社
WILEY
DOI: 10.1002/eji.200838516
关键词
Chronic lymphocytic leukemia; Fc receptor-like; Human cytotoxic T cells; Human NK cells
类别
资金
- National Institutes of Health [AI55638, AI007051]
- Dana Foundation
- V Foundation for Cancer Research
- Howard Hughes Medical Institute
- UAB
Fc receptor-like 6 (FCRL6), the most recently characterized member of the FCRL family, is a cell surface glycoprotein with tyrosine-based regulatory potential. An extensive survey of human hematopoietic tissues disclosed that FCRL6 expression by NK- and T-cell subpopulations increases as a function of differentiation and is remarkably restricted to mature lymphocytes with cytotoxic capability. In particular, FCRL6 distinguishes perforin-expressing CD56(dim) NK cells, V delta 1(+) and V delta 2(+) gamma delta T cells, effector and effector memory CD8(+) T cells, and rare cytotoxic CD4(+) T cells in adult tissues. Analysis of this receptor in B-cell chronic lymphocytic leukemia (CLL) was also performed. FCRL6 was found to mark significantly expanded populations of cytotoxic CD8+ T, CD4+ T, and NK cells in patients with CLL. Despite sequence homology with the known Fc receptors for IgG and IgE, FCRL6 did not bind Ig. Although FCRL6 can be tyrosine-phosphorylated, its antibody-mediated ligation was unable to influence cellular activation. Collectively, these results demonstrate that FCRL6 is a distinct indicator of cytotoxic effector lymphocytes that is upregulated in diseases characterized by chronic immune stimulation.
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