期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 38, 期 4, 页码 925-927出版社
WILEY
DOI: 10.1002/eji.200838168
关键词
Adaptive IL-10-producing Tr1 cells; FOXP3; Naturally occurring regulatory T cells
类别
资金
- Italian Telethon Foundation
FOXP3 is a specific marker for naturally occurring regulatory T cells (nTreg). FOXP3 expression is correlated with development and function of nTreg. Recent evidence suggests that, upon activation, human effector T (Teff) cells and type 1 regulatory T (Tr1) cells can express FOXP3, albeit transiently. While the role of transient FOXP3 expression in Teff cells is poorly understood, it is becoming clear that it does not correlate with suppressor function. Furthermore, FOXP3-independent mechanisms, mediated by IL-10, contribute to the induction and suppressor functions of Tr1 cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据